Paper Info
Title
Automated Dielectrophoretic Tweezers-Based Force Spectroscopy System in a Microfluidic Device.
Abstract
We reported an automated dielectrophoretic (DEP) tweezers-based force spectroscopy system to examine intermolecular weak binding interactions, which consists of three components: (1) interdigitated electrodes and micro-sized polystyrene particles used as DEP tweezers and probes inside a microfluidic device, along with an arbitrary function generator connected to a high voltage amplifier; (2) microscopy hooked up to a high-speed charge coupled device (CCD) camera with an image acquisition device; and (3) a computer aid control system based on the LabVIEW program. Using this automated system, we verified the measurement reliability by measuring intermolecular weak binding interactions, such as hydrogen bonds and Van der Waals interactions. In addition, we also observed the linearity of the force loading rates, which is applied to the probes by the DEP tweezers, by varying the number of voltage increment steps and thus affecting the linearity of the force loading rates. This system provides a simple and low-cost platform to investigate intermolecular weak binding interactions.
Year
DOI
Venue
2017
10.3390/s17102272
SENSORS
Keywords
Field
DocType
dielectrophoresis,force spectroscopy,force loading rate,intermolecular weak binding interactions
Nanotechnology,Tweezers,Analytical chemistry,Dielectrophoresis,Microfluidics,Chemistry,Electronic engineering,van der Waals force,Force spectroscopy,Microscopy,Intermolecular force,Charge-coupled device
Journal
Volume
Issue
ISSN
17
10.0
1424-8220
Citations 
PageRank 
References 
1
0.63
0
Authors
12
Name
Order
Citations
PageRank
Min Hyung Kim110.63
Jeongjick Lee210.63
Ki-Hwan Nam321.78
In Soo Park410.63
Myeonggu Son510.63
Hyun-Chul Ko631.00
Sangyoup Lee710.63
Dae Sung Yoon811.30
Woojin Chang93910.53
Sei Young Lee1010.96
Young Ro Yoon11101.64
Sang-Woo Lee1211.98