Name
Abstract | ||
|---|---|---|
Analysis of patient genomes and transcriptomes routinely recognizes new gene sets associated with human disease. Here we present an integrative natural language processing system which infers common functions for a gene set through automatic mining of the scientific literature with biological networks. This system links genes with associated literature phrases and combines these links with protein interactions in a single heterogeneous network. Multiscale functional annotations are inferred based on network distances between phrases and genes and then visualized as an ontology of biological concepts. To evaluate this system, we predict functions for gene sets representing known pathways and find that our approach achieves substantial improvement over the conventional text-mining baseline method. Moreover, our system discovers novel annotations for gene sets or pathways without previously known functions. Two case studies demonstrate how the system is used in discovery of new cancer-related pathways with ontological annotations. |
Year | Venue | Keywords |
|---|---|---|
2018 | Biocomputing-Pacific Symposium on Biocomputing | text mining,functional annotations,knowledge network,gene interactions |
Field | DocType | Volume |
Data science,Text mining,Gene,Biology,Bioinformatics | Conference | 23 |
ISSN | Citations | PageRank |
2335-6936 | 0 | 0.34 |
References | Authors | |
0 | 8 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Sheng Wang | 1 | 49 | 8.26 |
| Jianzhu Ma | 2 | 6 | 5.27 |
| Michael Ku Yu | 3 | 0 | 0.34 |
| Fan Zheng | 4 | 0 | 0.68 |
| Edward Huang | 5 | 2 | 2.39 |
| Jiawei Han | 6 | 43085 | 3824.48 |
| Peng, Jian | 7 | 430 | 50.07 |
| Trey Ideker | 8 | 1360 | 112.95 |