Paper Info
Title
Low-frequency direct cortical stimulation of left superior frontal gyrus enhances working memory performance.
Abstract
The neural substrates of working memory are spread across prefrontal, parietal and cingulate cortices and are thought to be coordinated through low frequency cortical oscillations in the theta (3–8 Hz) and alpha (8–12 Hz) frequency bands. While the functional role of many subregions have been elucidated using neuroimaging studies, the role of superior frontal gyrus (SFG) is not yet clear. Here, we combined electrocorticography and direct cortical stimulation in three patients implanted with subdural electrodes to assess if superior frontal gyrus is indeed involved in working memory. We found left SFG exhibited task-related modulation of oscillations in the theta and alpha frequency bands specifically during the encoding epoch. Stimulation at the frequency matched to the endogenous oscillations resulted in reduced reaction times in all three participants. Our results provide evidence for SFG playing a functional role in working memory and suggest that SFG may coordinate working memory through low-frequency oscillations thus bolstering the feasibility of using intracranial electric stimulation for restoring cognitive function.
Year
DOI
Venue
2019
10.1016/j.neuroimage.2018.09.064
NeuroImage
Field
DocType
Volume
Alpha (ethology),Superior frontal gyrus,Neuroscience,Electrocorticography,Biology,Working memory,Bioinformatics,Neuroimaging,Cognition,Stimulation,Encoding (memory)
Journal
184
ISSN
Citations 
PageRank 
1053-8119
1
0.34
References 
Authors
11
5
Name
Order
Citations
PageRank
Sankaraleengam Alagapan121.04
Caroline Lustenberger220.70
Eldad Hadar310.34
Hae Won Shin420.74
Flavio Fröhlich592.62