Title
Atrial Fibrosis Quantification Based on Maximum Likelihood Estimator of Multivariate Images.
Abstract
We present a fully-automated segmentation and quantification of the left atrial (LA) fibrosis and scars combining two cardiac MRIs, one is the target late gadolinium-enhanced (LGE) image, and the other is an anatomical MRI from the same acquisition session. We formulate the joint distribution of images using a multivariate mixture model (MvMM), and employ the maximum likelihood estimator (MLE) for texture classification of the images simultaneously. The MvMM can also embed transformations assigned to the images to correct the misregistration. The iterated conditional mode algorithm is adopted for optimization. This method first extracts the anatomical shape of the LA, and then estimates a prior probability map. It projects the resulting segmentation onto the LA surface, for quantification and analysis of scarring. We applied the proposed method to 36 clinical data sets and obtained promising results (Accuracy: 0.809 +/- .150, Dice: 0.556 +/- .187). We compared the method with the conventional algorithms and showed an evidently and statistically better performance (p < 0.03).
Year
DOI
Venue
2018
10.1007/978-3-030-00937-3_69
Lecture Notes in Computer Science
DocType
Volume
ISSN
Journal
11073
0302-9743
Citations 
PageRank 
References 
0
0.34
7
Authors
9
Name
Order
Citations
PageRank
Fuping Wu192.33
Lei Li2335.37
Guang Yang3155.73
Tom Wong4304.86
Raad Mohiaddin552540.16
David N. Firmin6684.54
J. Keegan710011.94
Lingchao Xu800.34
Xiahai Zhuang941138.76