Paper Info
Title
Discussion on Patients with Bipolar Disorder and Depressive Episode by Ratio Low Frequency Amplitude Combined with Grey Matter Volume Analysis.
Abstract
In order to explore the brain functional and structural imaging results of patients with bipolar disorder and depressive episode without taking medicine, and to further explore the disease mechanism of bipolar disorder by combining with clinical symptoms and cognitive function (neuropsychological test), DPABI (Data Processing and Analysis (Resting-State) For Brain Image) software is used to pre-process fMRI (functional magnetic resonance imaging) data and calculate fALFF (ratio low frequency fluctuation amplitude) index. In addition, SPM8 is applied for grey matter volume analysis based on voxel morphology. Pearson correlation model is used to analyze the relationship between functional and morphological changes and clinical symptoms and cognitive tests. DPABI software and SPSS 22.0 software are used to analyze the data. The results show that corresponding abnormal brain areas are found in both functional and structural aspects of patients with bipolar disorder and depression, involving LCSPT emotional circuits. More importantly, the superior frontal gyrus shows significant abnormalities in both functional and structural analysis.
Year
DOI
Venue
2019
10.1007/s10916-019-1212-x
Journal of medical systems
Keywords
Field
DocType
biphasic disorder,fALFF,grey matter volume analysis,resting-state fMRI
Voxel,Superior frontal gyrus,Neuropsychological test,Data mining,Cognitive test,Bipolar disorder,Grey matter,Functional magnetic resonance imaging,Resting state fMRI,Audiology,Medicine
Journal
Volume
Issue
ISSN
43
5
1573-689X
Citations 
PageRank 
References 
0
0.34
0
Authors
7
Name
Order
Citations
PageRank
Xiaohong Wang101.01
Na Zhao23716.03
Jingjing Shi3617.62
Yuhua Wu4827.70
Jun Liu523568.22
Qiang Xiao600.68
Jian Hu7107.03