Title
Hierarchical Structured Sparse Learning for Schizophrenia Identification.
Abstract
Fractional amplitude of low-frequency fluctuation (fALFF) has been widely used for resting-state functional magnetic resonance imaging (rs-fMRI) based schizophrenia (SZ) diagnosis. However, previous studies usually measure the fALFF within low-frequency fluctuation (from 0.01 to 0.08Hz), which cannot fully cover the complex neural activity pattern in the resting-state brain. In addition, existing studies usually ignore the fact that each specific frequency band can delineate the unique spontaneous fluctuations of neural activities in the brain. Accordingly, in this paper, we propose a novel hierarchical structured sparse learning method to sufficiently utilize the specificity and complementary structure information across four different frequency bands (from 0.01Hz to 0.25Hz) for SZ diagnosis. The proposed method can help preserve the partial group structures among multiple frequency bands and the specific characters in each frequency band. We further develop an efficient optimization algorithm to solve the proposed objective function. We validate the efficacy of our proposed method on a real SZ dataset. Also, to demonstrate the generality of the method, we apply our proposed method on a subset of Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. Experimental results on both datasets demonstrate that our proposed method achieves promising performance in brain disease classification, compared with several state-of-the-art methods.
Year
DOI
Venue
2020
10.1007/s12021-019-09423-0
Neuroinformatics
Keywords
Field
DocType
Schizophrenia, Fractional amplitude of low-frequency fluctuations (fALFF), Resting-state functional magnetic resonance imaging (rs-fMRI), Hierarchical feature selection
Functional magnetic resonance imaging,Pattern recognition,Frequency band,Computer science,Neural activity,Artificial intelligence,Neuroimaging,Radio spectrum,Schizophrenia,Generality,Machine learning,Sparse learning
Journal
Volume
Issue
ISSN
18
1
1539-2791
Citations 
PageRank 
References 
2
0.37
0
Authors
8
Name
Order
Citations
PageRank
Mingliang Wang1908.35
Xiaoke Hao2142.68
Jiashuang Huang362.78
Kangcheng Wang431.07
Li Shen5863102.99
Xijia Xu631.06
Daoqiang Zhang72862165.29
Mingxia Liu843241.14