Title | ||
---|---|---|
Unexpected complexity of the Reef-Building Coral <Emphasis Type="Italic">Acropora millepora</Emphasis> transcription factor network |
Abstract | ||
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Background Coral reefs are disturbed on a global scale by environmental changes including rising sea surface temperatures and ocean acidification.
Little is known about how corals respond or adapt to these environmental changes especially at the molecular level. This is
mostly because of the paucity of genome-wide studies on corals and the application of systems approaches that incorporate
the latter. Like in any other organism, the response of corals to stress is tightly controlled by the coordinated interplay
of many transcription factors.
Results Here, we develop and apply a new system-wide approach in order to infer combinatorial transcription factor networks of the
reef-building coral Acropora millepora. By integrating sequencing-derived transcriptome measurements, a network of physically interacting transcription factors,
and phylogenetic network footprinting we were able to infer such a network. Analysis of the network across a phylogenetically
broad sample of five species, including human, reveals that despite the apparent simplicity of corals, their transcription
factors repertoire and interaction networks seem to be largely conserved. In addition, we were able to identify interactions
among transcription factors that appear to be species-specific lending strength to the novel concept of "Taxonomically Restricted
Interactions".
Conclusions This study provides the first look at transcription factor networks in corals. We identified a transcription factor repertoire
encoded by the coral genome and found consistencies of the domain architectures of transcription factors and conserved regulatory
subnetworks across eumetazoan species, providing insight into how regulatory networks have evolved. |
Year | DOI | Venue |
---|---|---|
2011 | 10.1186/1752-0509-5-58 | BMC Systems Biology |
Keywords | Field | DocType |
Ocean Acidification, Transcriptional Network, Pfam Domain, Arcsine Transformation, Domain Composition | Coral,Ocean acidification,Ecology,Biology,Hermatypic coral,Acropora millepora,Coral reef,Anthozoa,Resilience of coral reefs,Reef | Journal |
Volume | Issue | ISSN |
5 | 1 | 1752-0509 |
Citations | PageRank | References |
5 | 0.35 | 5 |
Authors | ||
5 |
Name | Order | Citations | PageRank |
---|---|---|---|
Taewoo Ryu | 1 | 5 | 0.35 |
Charalampos Harris Mavromatis | 2 | 5 | 0.35 |
Till Bayer | 3 | 5 | 0.35 |
Christian R. Voolstra | 4 | 13 | 1.28 |
Timothy Ravasi | 5 | 35 | 2.37 |