Title
Exploitation of reverse vaccinology and immunoinformatics as promising platform for genome-wide screening of new effective vaccine candidates against <Emphasis Type="Italic">Plasmodium falciparum</Emphasis>
Abstract
The present study systematically screened 5 potential protective antigens from P. falciparum genome using bioinformatics tools. Interestingly, these GDPAA, RSKMA and EKE of P. falciparum epitope ensembles forecasted to contain highly promiscuous T cell epitopes, which are potentially effective for most of the world-wide human population with malaria endemic regions. Therefore, these epitope ensembles could be considered in near future for novel and significantly effective vaccine candidate against malaria.
Year
DOI
Venue
2019
10.1186/s12859-018-2482-x
BMC Bioinformatics
Keywords
Field
DocType
Malaria, Antigen, Epitopes, Population coverage, Vaccine, Plasmodium falciparum
Genome,Epitope,Population,Reverse vaccinology,Biology,MHC class I,Malaria vaccine,Plasmodium falciparum,Malaria,Genetics
Journal
Volume
Issue
ISSN
19
13
1471-2105
Citations 
PageRank 
References 
0
0.34
4
Authors
5