Name
Title | ||
|---|---|---|
Interrogation of evolving tumor vasculature using high-resolution CT imaging and a nanoparticle contrast agent. |
Abstract | ||
|---|---|---|
The architecture of intra-tumoral vascular network continuously evolves with tumor progression. Non-invasive methods that facilitate 3D in vivo interrogation of tumor vascular architecture could improve understanding of tumor progression and metastasis. In this work, we studied evolving tumor vasculature using high-resolution CT images and a blood-pool, nanoparticle iodinated contrast agent. In vivo studies were performed in a transgenic mouse model of neuroblastoma that exhibit spontaneous bilateral tumors in the adrenals. Animals were divided into three groups based on tumor age: early-age tumor, intermediate-age tumor, old-age tumor. Tumor progression was monitored using T2-weighted MRI. Contrast-enhanced CT imaging was performed at two points: the first imaging session (leak map) was performed 4 days after administration of the nanoparticle agent to interrogate changes in tumor vascular permeability. Immediately thereafter, a second dose of contrast agent was administered and CT imaging was performed within 1 hour to capture high-resolution angiograms of tumor vasculature. CT angiograms demonstrated the highly-vascularized nature of these tumors. Old-age tumors exhibited a higher fractional volume of avascular regions and an increased number of large superficial blood vessels on tumor periphery. Old-age tumors also demonstrated the presence of intra-vessel tumor thrombus and the invasion of tumor into the inferior vena cava. Leak maps images demonstrated signal enhancement throughout the tumor in early-age tumors, including the core region, suggestive of the presence of highly permeable blood vessels through the tumor volume. Old-age tumors exhibited relatively lower signal enhancement, indicative of a less 'leaky' tumor vascular network compared to early and intermediate-stage tumors. |
Year | DOI | Venue |
|---|---|---|
2018 | 10.1117/12.2293607 | Proceedings of SPIE |
Keywords | DocType | Volume |
cancer,neuroblastoma,angiogenesis,vascular,contrast agent,nanoparticle,liposome,CT imaging | Conference | 10578 |
ISSN | Citations | PageRank |
0277-786X | 0 | 0.34 |
References | Authors | |
0 | 5 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Ketan B. Ghaghada | 1 | 0 | 1.01 |
| Zbigniew Starosolski | 2 | 0 | 0.34 |
| Igor Stupin | 3 | 0 | 0.34 |
| Poonam Sarkar | 4 | 0 | 0.68 |
| Ananth Annapragada | 5 | 0 | 1.01 |