Title
A genetic programming-based regression for extrapolating a blood glucose-dynamics model from interstitial glucose measurements and their first derivatives.
Abstract
This paper illustrates the development and the applicability of an Evolutionary Computation approach to enhance the treatment of Type-1 diabetic patients that necessitate insulin injections. In fact, being such a disease associated to a malfunctioning pancreas that generates an insufficient amount of insulin, a way to enhance the quality of life of these patients is to implement an artificial pancreas able to artificially regulate the insulin dosage. This work aims at extrapolating a regression model, capable of estimating the blood glucose (BG) through interstitial glucose (IG) measurements and their numerical first derivatives. Such an approach represents a viable preliminary stage in building the basic component of this artificial pancreas. In particular, considered the high complexity of the reciprocal interactions, an evolutionary-based strategy is outlined to extrapolate a mathematical relationship between BG and IG and its derivative. The investigation is carried out about the accuracy of personalized models and of a global relationship model for all of the subjects under examination. The discovered models are assessed through a comparison with other models during the experiments on personalized and global data.
Year
DOI
Venue
2019
10.1016/j.asoc.2019.01.020
Applied Soft Computing
Keywords
Field
DocType
Blood glucose estimation,Interstitial glucose,Regression models,Genetic programming
Artificial pancreas,Regression,Regression analysis,Evolutionary computation,Genetic programming,Artificial intelligence,Insulin,Mathematics,Glucose Measurement,Machine learning
Journal
Volume
ISSN
Citations 
77
1568-4946
0
PageRank 
References 
Authors
0.34
0
8
Name
Order
Citations
PageRank
Ivanoe De Falco124234.58
Antonio Della Cioppa214120.70
A. Giugliano300.34
Angelo Marcelli413932.42
Tomas Koutny585.36
Michal Krcma611.72
Umberto Scafuri711616.33
Ernesto Tarantino836142.45