Title
Discriminative Pattern Mining for Breast Cancer Histopathology Image Classification via Fully Convolutional Autoencoder.
Abstract
Accurate diagnosis of breast cancer in histopathology images is challenging due to the heterogeneity of cancer cell growth as well as a variety of benign breast tissue proliferative lesions. In this paper, we propose a practical and self-interpretable invasive cancer diagnosis solution. With minimum annotation information, the proposed method mines contrast patterns between normal and malignant images in a weak-supervised manner and generate a probability map of abnormalities to verify its reasoning. Particularly, a fully convolutional autoencoder is used to learn the dominant structural patterns among normal image patches. Patches that do not share the characteristics of this normal population are detected and analyzed by one-class support vector machine and one-layer neural network. We apply the proposed method to a public breast cancer image set. Our results, in consultation with a senior pathologist, demonstrate that the proposed method outperforms existing methods. The obtained probability map could benefit the pathology practice by providing visualized verification data and potentially leads to a better understanding of data-driven diagnosis solutions.
Year
DOI
Venue
2019
10.1109/ACCESS.2019.2904245
IEEE ACCESS
Keywords
DocType
Volume
Breast cancer diagnosis,abnormality detection,convolutional autoencoder,discriminative pattern learning,histopathology image analysis
Journal
7
ISSN
Citations 
PageRank 
2169-3536
1
0.35
References 
Authors
21
4
Name
Order
Citations
PageRank
Xingyu Li1272.93
marko radulovic211.36
Ksenija Kanjer310.35
Konstantinos N. Plataniotis42135156.77