Paper Info
Title
Assessment of Diabetic Autonomic Nervous Dysfunction with a Novel Percussion Entropy Approach.
Abstract
This study investigated the validity of a novel parameter, percussion entropy index (PEI), for assessing baroreflex sensitivity. PEI was acquired through comparing the similarity in tendency of change between the amplitudes of successive digital volume pulse (DVP) signals and changes in R-R intervals (RRI) of successive cardiac cycles. Totally 108 upper middle-aged volunteers were divided into three groups: healthy subjects (Group 1, age 41-80, n=41), those with well-controlled type 2 diabetes mellitus (T2DM) (Group 2, age 41-82, n=36, glycated hemoglobin (HbA1c)<6.5%), and patients with poorly controlled T2DM (Group 3, age 44-77, n=31, HbA1c6.5%). Percussion entropy index (PEI) was computed from DVP signals acquired through photoplethysmography (PPG) and RRI from electrocardiogram in 1000 successive cardiac cycles for each subject. Autonomic function was also assessed by Poincare index (SD1/SD2 ratio, SSR), low- to high-frequency power ratio (LFP/HFP, LHR), and small-scale multiscale entropy index (MEISS) for comparison. Demographic, anthropometric, hemodynamic, and serum biochemical parameters of all testing subjects were obtained for investigating the significance of associations with the three parameters. The results showed that MEISS and PEI successfully discriminated among the three groups (p<0.017). However, only PEI showed significant associations with indicators of both acute (i.e., fasting blood sugar concentration, p<0.017) and chronic (i.e., HbA1c level, p<0.001) blood sugar control. Multivariate analysis also showed significant associations of PEI with fasting blood sugar and HbA1c levels in all subjects. The interpreting effect of the two independent variables, HbA1c level and fasting blood sugar concentration, on PEI was 71.4% and 12.3%, respectively. In conclusion, the results demonstrated that additional information on diabetic autonomic dysfunction can be obtained through comparing two simultaneously acquired physiological time series. The significant associations of percussion entropy index with indicators of blood sugar control also highlight its possible role in early screening of the disease.
Year
DOI
Venue
2019
10.1155/2019/6469853
COMPLEXITY
Field
DocType
Volume
Hemodynamics,Anthropometry,Baroreflex,Glycated hemoglobin,Internal medicine,Control theory,Photoplethysmogram,Cardiology,Pulse (signal processing),Blood sugar,Multivariate analysis,Mathematics
Journal
2019
ISSN
Citations 
PageRank 
1076-2787
0
0.34
References 
Authors
6
5
Name
Order
Citations
PageRank
Hai-Cheng Wei121.74
Ming-Xia Xiao221.40
Na Ta311.30
Hsien-Tsai Wu424230.90
Cheuk-Kwan Sun56510.19