Paper Info
Title
Influence of Duodenal-Jejunal Implantation on Glucose Dynamics: A Pilot Study Using Different Nonlinear Methods.
Abstract
Diabetes is a disease of great and rising prevalence, with the obesity epidemic being a significant contributing risk factor. Duodenal-jejunal bypass liner (DJBL) is a reversible implant that mimics the effects of more aggressive surgical procedures, such as gastric bypass, to induce weight loss. We hypothesized that DJBL also influences the glucose dynamics in type II diabetes, based on the induced changes already demonstrated in other physiological characteristics and parameters. In order to assess the validity of this assumption, we conducted a quantitative analysis based on several nonlinear algorithms (Lempel-Ziv Complexity, Sample Entropy, Permutation Entropy, and modified Permutation Entropy), well suited to the characterization of biomedical time series. We applied them to glucose records drawn from two extreme cases available of DJBL implantation: before and after 10 months. The results confirmed the hypothesis and an accuracy of 86.4% was achieved with modified Permutation Entropy. Other metrics also yielded significant classification accuracy results, all above 70%, provided a suitable parameter configuration was chosen. With the Leave-One-Out method, the results were very similar, between 72% and 82% classification accuracy. There was also a decrease in entropy of glycaemia records during the time interval studied. These findings provide a solid foundation to assess how glucose metabolism may be influenced by DJBL implantation and opens a new line of research in this field.
Year
DOI
Venue
2019
10.1155/2019/6070518
COMPLEXITY
Field
DocType
Volume
Diabetes mellitus,Nonlinear algorithms,Sample entropy,Control theory,Nonlinear methods,Permutation entropy,Type ii diabetes,Statistics,Weight loss,Mathematics
Journal
2019
ISSN
Citations 
PageRank 
1076-2787
0
0.34
References 
Authors
9
11
Name
Order
Citations
PageRank
D. Cuesta-Frau114923.78
Daniel Novák2269.29
Vaclav Burda300.68
Daniel Abásolo425326.22
Tricia Adjei530.78
manuel varela630.83
Borja Vargas7182.56
Milos Mraz800.68
Petra Kavalkova900.68
Marek Benes1000.68
Martin Haluzik1100.68