Name
Title | ||
|---|---|---|
GalaxyTongDock: Symmetric and asymmetric ab initio protein-protein docking web server with improved energy parameters. |
Abstract | ||
|---|---|---|
Protein-protein docking methods are spotlighted for their roles in providing insights into protein-protein interactions in the absence of full structural information by experiment. GalaxyTongDock is an ab initio protein-protein docking web server that performs rigid-body docking just like ZDOCK but with improved energy parameters. The energy parameters were trained by iterative docking and parameter search so that more native-like structures are selected as top rankers. GalaxyTongDock performs asymmetric docking of two different proteins (GalaxyTongDock_A) and symmetric docking of homo-oligomeric proteins with C-n and D-n symmetries (GalaxyTongDock_C and GalaxyTongDock_D). Performance tests on an unbound docking benchmark set for asymmetric docking and a model docking benchmark set for symmetric docking showed that GalaxyTongDock is better or comparable to other state-of-the-art methods. Experimental and/or evolutionary information on binding interfaces can be easily incorporated by using block and interface options. GalaxyTongDock web server is freely available at . (c) 2019 Wiley Periodicals, Inc. |
Year | DOI | Venue |
|---|---|---|
2019 | 10.1002/jcc.25874 | JOURNAL OF COMPUTATIONAL CHEMISTRY |
Keywords | Field | DocType |
protein-protein docking,GalaxyTongDock,complex structure modeling,complex structure prediction,web server | Docking (dog),Computational chemistry,Chemistry,Protein protein,Ab initio,Web server | Journal |
Volume | Issue | ISSN |
40.0 | 27 | 0192-8651 |
Citations | PageRank | References |
0 | 0.34 | 0 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Taeyong Park | 1 | 2 | 1.05 |
| Minkyung Baek | 2 | 2 | 1.38 |
| Hasup Lee | 3 | 4 | 2.19 |
| Chaok Seok | 4 | 163 | 15.89 |