Title
Multi-Scale Simulation Modeling for Prevention and Public Health Management of Diabetes in Pregnancy and Sequelae
Abstract
Diabetes in pregnancy (DIP) is an increasing public health priority in the Australian Capital Territory, particularly due to its impact on risk for developing Type 2 diabetes. While earlier diagnostic screening results in greater capacity for early detection and treatment, such benefits must be balanced with the greater demands this imposes on public health services. To address such planning challenges, a multi-scale hybrid simulation model of DIP was built to explore the interaction of risk factors and capture the dynamics underlying the development of DIP. The impact of interventions on health outcomes at the physiological, health service and population level is measured. Of particular central significance in the model is a compartmental model representing the underlying physiological regulation of glycemic status based on beta-cell dynamics and insulin resistance. The model also simulated the dynamics of continuous BMI evolution, glycemic status change during pregnancy and diabetes classification driven by the individual-level physiological model. We further modeled public health service pathways providing diagnosis and care for DIP to explore the optimization of resource use during service delivery. The model was extensively calibrated against empirical data.
Year
DOI
Venue
2019
10.1007/978-3-030-21741-9_26
Lecture Notes in Computer Science
Keywords
Field
DocType
Gestational diabetes mellitus,Agent based model,System dynamic model,Discrete event model
Public health,Population,Internet privacy,Psychological intervention,Agent-based model,Type 2 diabetes,Computer science,Pregnancy,Risk analysis (engineering),Service delivery framework,Glycemic
Conference
Volume
ISSN
Citations 
11549
0302-9743
0
PageRank 
References 
Authors
0.34
0
6
Name
Order
Citations
PageRank
Yang Qin101.01
Louise Freebairn200.34
Jo-An Atkinson300.68
Weicheng Qian4233.61
Anahita Safarishahrbijari500.34
Nathaniel D. Osgood6239.92