Paper Info
Title
A Wireless Handheld Pressure Measurement System for in vivo Monitoring of Intraocular Pressure in Rabbits.
Abstract
Intraocular pressure (IOP) is the leading modifiable risk factor for preventing vision loss in glaucoma patients. Direct and frequent IOP measurements are highly desirable to assess adequacy of treatment and prevent further vision loss. In this study, we report on successful <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in vivo</italic> measurements of intraocular pressure in rabbits using an optical IOP measurement system. The sensor was implanted during cataract surgery in two New Zealand white (NZW) rabbits and tested <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in vivo</italic> for ten weeks. Prior to implantation, the sensors were characterized <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in vitro</italic> in the physiologically relevant pressure range of 0–60 mmHg. A portable wireless handheld reader consisting of an internal beam splitter, a monochromatic light source, and a digital single-lens reflex (DSLR) camera was also designed and implemented to capture interference patterns from the sensor. The sensitivity and accuracy of the sensor was 30 nm/mmHg and ±0.2 mmHg, respectively. Ten weeks post-implantation, the two NZW rabbits continued to respond well to the implant with no observable inflammation, signs of infection, or biofouling. All IOP measurements were obtained using the portable DSLR handheld reader. Successful <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in vivo</italic> studies demonstrate biocompatibility of the IOP sensor and prove feasibility of the IOP measurement system. The system has the potential to be used in both clinical and patient point-of-care (home) settings to frequently and accurately measure pressure.
Year
DOI
Venue
2020
10.1109/TBME.2019.2924440
IEEE transactions on bio-medical engineering
Keywords
Field
DocType
Intraocular pressure sensor,reader,pressure,measurement system,interferometry,glaucoma
Biomedical engineering,Wireless,Computer science,Pressure measurement,Intraocular pressure,Electronic engineering,In vivo,Mobile device
Journal
Volume
Issue
ISSN
67
3
0018-9294
Citations 
PageRank 
References 
0
0.34
0
Authors
7
Name
Order
Citations
PageRank
Alex Phan100.34
Phuong Truong200.34
Andrew Camp301.35
Kerrianne Stewart400.34
Benjamin Suen500.34
Robert N Weinreb6589.90
Frank E. Talke721.75