Paper Info
Title
Neurovascular decoupling in type 2 diabetes mellitus without mild cognitive impairment: Potential biomarker for early cognitive impairment.
Abstract
Type 2 diabetes mellitus (T2DM) is a significant risk factor for mild cognitive impairment (MCI) and the acceleration of MCI to dementia. The high glucose level induce disturbance of neurovascular (NV) coupling is suggested to be one potential mechanism, however, the neuroimaging evidence is still lacking. To assess the NV decoupling pattern in early diabetic status, 33 T2DM without MCI patients and 33 healthy control subjects were prospectively enrolled. Then, they underwent resting state functional MRI and arterial spin labeling imaging to explore the hub-based networks and to estimate the coupling of voxel-wise cerebral blood flow (CBF)-degree centrality (DC), CBF-mean amplitude of low-frequency fluctuation (mALFF) and CBF- mean regional homogeneity (mReHo). We further evaluated the relationship between NV coupling pattern and cognitive performance (false discovery rate corrected). T2DM without MCI patients displayed significant decrease in the absolute CBF-mALFF, CBF-mReHo coupling of CBFnetwork and in the CBF-DC coupling of DCnetwork. Besides, networks which involved CBF and DC hubs mainly located in the default mode network (DMN). Furthermore, less severe disease and better cognitive performance in T2DM patients were significantly correlated with higher coupling of CBF-DC, CBF-mALFF or CBF-mReHo, especially for the cognitive dimensions of general function and executive function. Thus, coupling of CBF-DC, CBF-mALFF and CBF-mReHo may serve as promising indicators to reflect NV coupling state and to explain the T2DM related early cognitive impairment.
Year
DOI
Venue
2019
10.1016/j.neuroimage.2019.06.058
NeuroImage
Keywords
Field
DocType
Type 2 diabetes mellitus,Cognitive impairment,Neurovascular coupling,Default mode network,Executive function
Diabetes mellitus,Default mode network,Internal medicine,Resting state fMRI,Cardiology,Cognitive psychology,Psychology,Cerebral blood flow,Type 2 Diabetes Mellitus,Neuroimaging,Effects of sleep deprivation on cognitive performance,Dementia
Journal
Volume
ISSN
Citations 
200
1053-8119
0
PageRank 
References 
Authors
0.34
0
18
Name
Order
Citations
PageRank
Ying Yu141.45
Lin-Feng Yan211.41
Qian Sun32810.81
Bo Hu48719.00
Jin Zhang535347.68
Yang Yang660.77
Yu-Jie Dai700.34
Wu-Xun Cui800.34
Si-Jie Xiu900.34
Yu-Chuan Hu1000.68
Chun-Ni Heng1100.34
Qing-Quan Liu1200.34
Jun-Feng Hou1300.34
Yu-Yun Pan1400.34
Liang-Hao Zhai1500.34
Teng-Hui Han1600.34
Guangbin Cui1732.85
Wen Wang1822.16