Name
Title | ||
|---|---|---|
A Multiscale Model Of Atherosclerotic Plaque Development: Toward A Coupling Between An Agent-Based Model And Cfd Simulations |
Abstract | ||
|---|---|---|
Computational models have been widely used to predict the efficacy of surgical interventions in response to Peripheral Occlusive Diseases. However, most of them lack a multiscale description of the development of the disease, which, in our hypothesis, is the key to develop an effective predictive model. Accordingly, in this work we present a multiscale computational framework that simulates the generation of atherosclerotic arterial occlusions. Starting from a healthy artery in homeostatic conditions, the perturbation of specific cellular and extracellular dynamics led to the development of the pathology, with the final output being a diseased artery. The presented model was developed on an idealized portion of a Superficial Femoral Artery (SFA), where an Agent-Based Model (ABM), locally replicating the plaque development, was coupled to Computational Fluid Dynamics (CFD) simulations that define the Wall Shear Stress (WSS) profile at the lumen interface. The ABM was qualitatively validated on histological images and a preliminary analysis on the coupling method was conducted. Once optimized the coupling method, the presented model can serve as a predictive platform to improve the outcome of surgical interventions such as angioplasty and stent deployment. |
Year | DOI | Venue |
|---|---|---|
2019 | 10.1007/978-3-030-22747-0_31 | COMPUTATIONAL SCIENCE - ICCS 2019, PT IV |
Keywords | Field | DocType |
Agent-Based Model, Computational Fluid Dynamics, Peripheral Occlusive Diseases, Atherosclerosis, Multiscale model | Biomedical engineering,Mathematical optimization,Agent-based model,Coupling,Computer science,Arterial occlusions,Computational model,Femoral artery,Computational fluid dynamics,Angioplasty | Conference |
Volume | ISSN | Citations |
11539 | 0302-9743 | 0 |
PageRank | References | Authors |
0.34 | 0 | 6 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Anna Corti | 1 | 0 | 0.34 |
| Stefano Casarin | 2 | 0 | 1.01 |
| Claudio Chiastra | 3 | 0 | 0.68 |
| Monika Colombo | 4 | 0 | 0.34 |
| Francesco Migliavacca | 5 | 3 | 2.89 |
| Marc Garbey | 6 | 251 | 54.94 |