Name
Title | ||
|---|---|---|
In silico and in vitro identification of candidate SIRT1 activators from Indonesian medicinal plants compounds database. |
Abstract | ||
|---|---|---|
•Structure-based pharmacophores screening predicted that mulberrin as the potential candidate SIRT1 activator.•Ligand-based pharmacophores screening predicted that gartanin, quinidine, and quinine are the likely candidates SIRT1 activator.•The MM-GB(PB)SA calculations confirmed that mulberrin, gartanin, quinidine, and quinine showed activity at SIRT1 allosteric region.•Mulberrin, gartanin, quinidine, and quinine have been proven by in vitro assay as SIRT1 activator candidates. |
Year | DOI | Venue |
|---|---|---|
2019 | 10.1016/j.compbiolchem.2019.107096 | Computational Biology and Chemistry |
Keywords | Field | DocType |
SIRT1 activator,Pharmacophore-based,Virtual screening,Indonesia medicinal plants database (HerbalDB),Molecular dynamics simulation | Docking (molecular),Pharmacophore,Biology,In vitro,Allosteric regulation,Quinidine,Activator (genetics),Virtual screening,Database,In silico | Journal |
Volume | Issue | ISSN |
83 | C | 1476-9271 |
Citations | PageRank | References |
0 | 0.34 | 0 |
Authors | ||
6 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Azminah Azminah | 1 | 0 | 0.34 |
| Linda Erlina | 2 | 0 | 0.34 |
| Maksum Radji | 3 | 0 | 0.34 |
| Abdul Mun'im | 4 | 0 | 0.34 |
| Rezi Riadhi Syahdi | 5 | 0 | 0.34 |
| Arry Yanuar | 6 | 0 | 1.35 |