Name
Title | ||
|---|---|---|
breakpointR: an R/Bioconductor package to localize strand state changes in Strand-seq data. |
Abstract | ||
|---|---|---|
Motivation: Strand-seq is a specialized single-cell DNA sequencing technique centered around the directionality of single-stranded DNA. Computational tools for Strand-seq analyses must capture the strand-specific information embedded in these data. Results: Here we introduce breakpointR, an R/Bioconductor package specifically tailored to process and interpret single-cell strand-specific sequencing data obtained from Strand-seq. We developed breakpointR to detect local changes in strand directionality of aligned Strand-seq data, to enable fine-mapping of sister chromatid exchanges, germline inversion and to support global haplotype assembly. Given the broad spectrum of Strand-seq applications we expect breakpointR to be an important addition to currently available tools and extend the accessibility of this novel sequencing technique. |
Year | DOI | Venue |
|---|---|---|
2020 | 10.1093/bioinformatics/btz681 | BIOINFORMATICS |
Field | DocType | Volume |
Data mining,Computer science,Bioconductor | Journal | 36 |
Issue | ISSN | Citations |
4 | 1367-4803 | 0 |
PageRank | References | Authors |
0.34 | 0 | 6 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| David Porubsky | 1 | 0 | 0.34 |
| Ashley D. Sanders | 2 | 0 | 1.35 |
| Aaron Taudt | 3 | 2 | 0.76 |
| Maria Colomé-Tatché | 4 | 5 | 1.26 |
| Peter M. Lansdorp | 5 | 1 | 0.77 |
| Victor Guryev | 6 | 26 | 5.53 |