Paper Info
Title
Monitoring of Adult Zebrafish Heart Regeneration Using High-Frequency Ultrasound Spectral Doppler and Nakagami Imaging.
Abstract
This paper reports the feasibility of Nakagami imaging in monitoring the regeneration process of zebrafish hearts in a noninvasive manner. In addition, spectral Doppler waveforms that are typically used to access the diastolic function were measured to validate the performance of Nakagami imaging. A 30-MHz high-frequency ultrasound array transducer was used to acquire backscattered echo signal for spectral Doppler and Nakagami imaging. The performances of both methods were validated with flow and tissue-mimicking phantom experiments. For in vivo experiments, both spectral Doppler and Nakagami imaging were simultaneously obtained from adult zebrafish with amputated hearts. Longitudinal measurements were performed for five zebrafish. From the experiments, the E/A ratio measured using spectral Doppler imaging increased at 3 days post-amputation (3 dpa) and then decreased to the value before amputation, which were consistent with previous studies. Similar results were obtained from the Nakagami imaging where the Nakagami parameter value increased at 3 dpa and decreased to its original value. These results suggested that the Nakagami and spectral Doppler imaging would be useful techniques in monitoring the regeneration of heart or tissues.
Year
DOI
Venue
2019
10.3390/s19194094
SENSORS
Keywords
Field
DocType
high-frequency ultrasound,Nakagami imaging,spectral Doppler,zebrafish
Biomedical engineering,Transducer,Doppler imaging,Imaging phantom,Diastolic function,Electronic engineering,Nakagami distribution,Engineering,Doppler effect,Ultrasound
Journal
Volume
Issue
ISSN
19
19.0
1424-8220
Citations 
PageRank 
References 
0
0.34
0
Authors
5
Name
Order
Citations
PageRank
Sunmi Yeo101.35
Changhan Yoon2113.33
Ching-Ling Lien300.34
Tai-Kyong Song4115.27
K. Kirk Shung510010.41