Paper Info
Title
Extracellular Stimulation Of Neural Tissues: Activating Function And Sub-Threshold Potential Perspective
Abstract
Electric stimulation of neural tissues has been an effective clinical intervention to address a variety of pathological issues such as profound deafness, retinal diseases, and Parkinson's disease. However, the knowledge about the exact mechanism of neural excitation, especially activation sites is still ambiguous. Nevertheless, in silico models utilize two approaches namely activating function and sub-threshold potential to predict the activation sites of neural tissues. This paper studies the applicability of these two approaches to model the electric stimulation of pyramidal neuron and spiral ganglion neurons using finite element models. The simulation results suggest that the activating function could be prone to geometrical irregularities of the neural tissues, yet realistically predicts the activation sites on the myelinated neurons. In contrast, the sub-threshold potential predicts the activation of unmyelinated axons by considering the electrophysiological properties of neural tissues. The present study suggests that it is necessary to choose an appropriate method to estimate the neural activation sites while modeling the extracellular stimulation of neural tissues.
Year
DOI
Venue
2019
10.1109/EMBC.2019.8857113
2019 41ST ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
Field
DocType
Volume
Computer vision,Threshold potential,Neuroscience,Computer science,Extracellular,Artificial intelligence,Spiral ganglion,Activating function,Neural tissues,Stimulation,Electrophysiology,In silico
Conference
2019
ISSN
Citations 
PageRank 
1557-170X
0
0.34
References 
Authors
0
3
Name
Order
Citations
PageRank
Revathi Appali100.34
Kiran K. Sriperumbudur200.68
Ursula van Rienen346.19