Paper Info
Title
Characterizing Fluid Response And Sepsis Progression In Emergency Department Patients
Abstract
Sepsis and septic shock are major global public health concerns. The main therapies for sepsis-related hypotension are fluid resuscitation and vasopressor therapy, though it can be challenging to determine the amount of fluid that should be given or the optimal timing to transition to vasopressor administration. To characterize patients' response to fluid bolus therapy (FBT) and analyze the sepsis progress using multiple vital signs, we mined a database containing 761 patients presenting to the Emergency Department (ED) with vital signs and laboratory values indicating high risk of septic shock. By clustering the patients' mean arterial pressure (MAP) time series during a time window around FBT, we found that clusters showing fluid responsiveness during the two hours after FBT only included about 25% of studied boluses. In addition, MAP responses tended to vary based on the initial MAP level. We also found that the trajectories of heart rate and MAP in a 2-D plane demonstrated general trends related to the hemodynamic progression of sepsis and previously described phases of septic shock. Potentially compensatory and decompensatory responses of the cardiovascular system to the insults of sepsis were reflected in the clusters representative of different phases.
Year
DOI
Venue
2019
10.1109/EMBC.2019.8856521
2019 41ST ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
Field
DocType
Volume
Computer science,Vital signs,Artificial intelligence,Heart rate,Resuscitation,Hemodynamics,Computer vision,Septic shock,Internal medicine,Emergency department,Cardiology,Mean arterial pressure,Sepsis
Conference
2019
ISSN
Citations 
PageRank 
1557-170X
0
0.34
References 
Authors
0
3
Name
Order
Citations
PageRank
Qiao Gu100.34
Varesh Prasad201.69
Thomas Heldt329.54