Paper Info
Title
Role Of I-F Density On Electrical Action Potential Of Bio-Engineered Cardiac Pacemaker: A Simulation Study
Abstract
Due to the inevitable drawbacks of the implantable electrical pacemaker, the biological pacemaker was believed to be an alternative therapy for heart failure. Previous experimental studies have shown that biological pacemaker could be produced by genetically manipulating non-pacemaking cardiac cells by suppressing the inward rectifier potassium current (I-K1) and expressing the hyperpolarization- activated current (I-f). However, the role of I-f in such bio-engineered pacemaker is not clear. In this study, we simulated the action potential of biological pacemaker cells by manipulating I-f-I-K1 parameters (i.e., inhibiting I-K1 as well as incorporating I-f) to analyze possible mechanisms by which different I-f densities control pacemaking action potentials. Our simulation results showed different pacing mechanism between the bioengineered pacemaking cells with and without I-f. In addition, it was shown that a greater I-f density might result in a slower pacing frequency, and excessive of it might produce an early-afterdepolarizations-like action potential due to a sudden release of calcium from sarcoplasmic reticulum into the cytoplasm. This study indicated that when I-K1 was significantly suppressed, incorporating I-f may not enhance the pacing ability of biological pacemaker, but lead to abnormal dynamics of intracellular ionic concentration, increasing risks of dysrhythmia in the heart.
Year
DOI
Venue
2019
10.1109/EMBC.2019.8856350
2019 41ST ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
DocType
Volume
ISSN
Conference
2019
1557-170X
Citations 
PageRank 
References 
0
0.34
0
Authors
5
Name
Order
Citations
PageRank
Yacong Li105.07
Kuanquan Wang21617141.11
Qince Li379.91
Cunjin Luo418.06
Henggui Zhang510551.88