Paper Info
Title
Characterization Of Eeg Resting-State Activity In Alzheimer'S Disease By Means Of Recurrence Plot Analyses
Abstract
The main objective of this study was to characterize EEG resting-state activity in 55 Alzheimer's disease (AD) patients and 29 healthy controls by means of TREND, a measure based on recurrence quantification analysis. TREND was computed from 60-second recordings of consecutive EEG activity, divided into non-overlapping windows of length 1, 2, 3, 5, 10, 15, 20 and 60 seconds. This measure was computed in the conventional EEG frequency bands (delta, theta, alpha, beta-1, beta-2 and gamma). The parameters delay (tau) and embedding dimension (m) were first optimized for every window size and frequency band under study. These embedding parameters proved to be frequency-dependent. Furthermore, 10 s epochs were set as the minimum length required to avoid spurious results. Statistically significant differences between both groups were found (p < 0.05, Mann-Whitney U-test). The groups showed differences in TREND in the theta (4-8 Hz), beta-1 (13-19 Hz) and beta-2 (19-30 Hz) frequency bands. Our results using TREND suggest that AD disrupts resting-state neural dynamics. Furthermore, these findings indicate that AD induces a frequency-dependent pattern of alterations in the non-stationarity levels of resting-state neural activity.
Year
DOI
Venue
2019
10.1109/EMBC.2019.8856600
2019 41ST ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
Field
DocType
Volume
Alpha (ethology),Computer vision,Computer science,Frequency band,Resting state fMRI,Neural activity,Artificial intelligence,Recurrence quantification analysis,Nuclear magnetic resonance,Electroencephalography,Recurrence plot
Conference
2019
ISSN
Citations 
PageRank 
1557-170X
0
0.34
References 
Authors
0
9
Name
Order
Citations
PageRank
Pablo Nuñez100.34
Jesús Poza25512.29
Carlos Gómez38615.72
Verónica Barroso-García466.59
Saúl J. Ruiz-Gómez501.01
Aaron Maturana-Candelas600.68
Miguel A. Tola-Arribas752.58
Monica Cano850.89
Roberto Hornero960367.74