Title
Estimation of cerebral blood flow velocity during breath-hold challenge using artificial neural networks.
Abstract
The effect of untreated Obstructive Sleep Apnoea (OSA) on cerebral haemodynamics and CA impairment is an active field of research interest. A breath-hold challenge is usually used in clinical and research settings to simulate cardiovascular and cerebrovascular changes that mimic OSA events. This work utilises temporal arterial oxygen saturation (SpO2) and photoplethysmography (PPG) signals to estimate the temporal cerebral blood flow velocity (CBFv) waveform. Measurements of CBFv, SpO2, and PPG, were acquired concurrently from volunteers performing two different protocols of breath-hold challenge in the supine position. Past values of the SpO2 and PPG signals were used to estimate the current values of CBFv using different permutations and topologies of supervised learning with shallow artificial neural networks (ANNs). The measurements from one protocol were used to train the ANNs and find the optimum topologies, which in turn were tested using the other protocol. Data collected from 10 normotensive, healthy subjects (four females, age 28.5 ± 6.1 years, Body Mass Index (BMI) 24.0 ± 4.7 kg/m2) were used in this study. The results show that different subjects have different optimum topologies for ANNs, thus indicating the effects of inter-subject variability on ANNs. Successfully reconstructed blind waveforms for the same subject group in the second protocol showed a reasonable accuracy of 60–80% estimation compared to the measured waveforms.
Year
DOI
Venue
2019
10.1016/j.compbiomed.2019.103508
Computers in Biology and Medicine
Keywords
Field
DocType
Cerebral blood flow velocity,Blood oxygen saturation,Photoplethysmography,Machine learning,Time series estimation,Biomedical signal processing,Obstructive sleep apnea,Breath-hold challenge
Population,Pattern recognition,Computer science,Photoplethysmogram,Transcranial Doppler,Waveform,Supervised learning,Artificial intelligence,Cerebral blood flow,Artificial neural network,Pulse oximetry
Journal
Volume
ISSN
Citations 
115
0010-4825
0
PageRank 
References 
Authors
0.34
0
7