Paper Info
Title
Learning complex subcellular distribution patterns of proteins via analysis of immunohistochemistry images.
Abstract
Motivation: Systematic and comprehensive analysis of protein subcellular location as a critical part of proteomics ('location proteomics') has been studied for many years, but annotating protein subcellular locations and understanding variation of the location patterns across various cell types and states is still challenging. Results: In this work, we used immunohistochemistry images from the Human Protein Atlas as the source of subcellular location information, and built classification models for the complex protein spatial distribution in normal and cancerous tissues. The models can automatically estimate the fractions of protein in different subcellular locations, and can help to quantify the changes of protein distribution from normal to cancer tissues. In addition, we examined the extent to which different annotated protein pathways and complexes showed similarity in the locations of their member proteins, and then predicted new potential proteins for these networks.
Year
DOI
Venue
2020
10.1093/bioinformatics/btz844
BIOINFORMATICS
Field
DocType
Volume
Data mining,Computer science,Computational biology,Immunohistochemistry
Journal
36
Issue
ISSN
Citations 
6
1367-4803
0
PageRank 
References 
Authors
0.34
0
3
Name
Order
Citations
PageRank
Ying-Ying Xu101.35
Hongbin Shen253348.23
Robert F Murphy385178.19