Title
Recent Developments of High-Resolution Chemical Imaging Systems Based on Light-Addressable Potentiometric Sensors (LAPSs).
Abstract
A light-addressable potentiometric sensor (LAPS) is a semiconductor electrochemical sensor based on the field-effect which detects the variation of the Nernst potential on the sensor surface, and the measurement area is defined by illumination. Thanks to its light-addressability feature, an LAPS-based chemical imaging sensor system can be developed, which can visualize the two-dimensional distribution of chemical species on the sensor surface. This sensor system has been used for the analysis of reactions and diffusions in various biochemical samples. In this review, the LAPS system set-up, including the sensor construction, sensing and substrate materials, modulated light and various measurement modes of the sensor systems are described. The recently developed technologies and the affecting factors, especially regarding the spatial resolution and temporal resolution are discussed and summarized, and the advantages and limitations of these technologies are illustrated. Finally, the further applications of LAPS-based chemical imaging sensors are discussed, where the combination with microfluidic devices is promising.
Year
DOI
Venue
2019
10.3390/s19194294
SENSORS
Keywords
Field
DocType
LAPS,chemical imaging,spatial and temporal resolution,semiconductor,microfluidics
Potentiometric sensor,Chemical species,Microfluidics,Electronic engineering,Electrochemical gas sensor,Engineering,Optoelectronics,Temporal resolution,Image resolution,Chemical imaging,Nernst equation
Journal
Volume
Issue
ISSN
19
19
1424-8220
Citations 
PageRank 
References 
0
0.34
0
Authors
7
Name
Order
Citations
PageRank
Tao Liang100.34
Yong Qiu200.34
Ying Gan300.34
Jiadi Sun400.34
Shuqi Zhou500.34
Hao Wan601.35
Ping Wang71012.69