Paper Info
Title
Detection of the Strains Induced in Murine Tibias by Ex Vivo Uniaxial Loading with Different Sensors.
Abstract
In this paper, the characterization of the main techniques and transducers employed to measure local and global strains induced by uniaxial loading of murine tibiae is presented. Micro strain gauges and digital image correlation (DIC) were tested to measure local strains, while a moving coil motor-based length transducer was employed to measure relative global shortening. Local strain is the crucial parameter to be measured when dealing with bone cell mechanotransduction, so we characterized these techniques in the experimental conditions known to activate cell mechanosensing in vivo. The experimental tests were performed using tibia samples excised from twenty-two C57BL/6 mice. To evaluate measurement repeatability we computed the standard deviation of ten repetitive compressions to the mean value. This value was lower than 3% for micro strain gauges, and in the range of 7%-10% for DIC and the length transducer. The coefficient of variation, i.e., the standard deviation to the mean value, was about 35% for strain gauges and the length transducer, and about 40% for DIC. These results provided a comprehensive characterization of three methodologies for local and global bone strain measurement, suggesting a possible field of application on the basis of their advantages and limitations.
Year
DOI
Venue
2019
10.3390/s19235109
SENSORS
Keywords
DocType
Volume
strain measurement,digital image correlation (DIC),strain gauges,tissue biomechanics,mechanotransduction,uniaxial loading,bone tissue
Journal
19
Issue
ISSN
Citations 
23.0
1424-8220
0
PageRank 
References 
Authors
0.34
0
8
Name
Order
Citations
PageRank
Emanuele Rizzuto124.25
Barbara Peruzzi201.01
Mariagrazia Giudice300.34
Enrica Urciuoli400.34
Erika Pittella5104.90
Emanuele Piuzzi6148.11
Antonio Musarò700.34
Zaccaria Del Prete8910.45