Title
Combining Multiple Behavioral Measures and Multiple Connectomes via Multipath Canonical Correlation Analysis.
Abstract
Functional connectomes can successfully predict behavioral measures. While the majority of the literature uses a single connectome to predict a single behavioral measure, there is ample evidence that combining different connectomes and behavioral measures reveals more robust neural correlates. Here, we proposed a prediction framework that combines connectomes from multiple sources (e.g. task and resting-state fMRI) and predicts a latent phenotype, derived from a battery of behavioral measures. The framework relies on a novel generalization of canonical correlation analysis with both a closed-form and an iterative solution. We applied the framework to data from the Human Connectome Project (HCP) to predict a latent, general intelligence factor. Prediction accuracy was higher for this latent factor than any single measure of intelligence, showing the advantage of combining multiple connectomes and behavioral measures in a single predictive model.
Year
DOI
Venue
2019
10.1007/978-3-030-32248-9_86
Lecture Notes in Computer Science
DocType
Volume
ISSN
Conference
11766
0302-9743
Citations 
PageRank 
References 
0
0.34
0
Authors
4
Name
Order
Citations
PageRank
Siyuan Gao1182.00
Xilin Shen200.34
R Todd Constable384877.34
Dustin Scheinost421.73