Title | ||
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Diffusion time dependency along the human corpus callosum and exploration of age and sex differences as assessed by oscillating gradient spin-echo diffusion tensor imaging. |
Abstract | ||
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Conventional diffusion imaging uses pulsed gradient spin echo (PGSE) waveforms with diffusion times of tens of milliseconds (ms) to infer differences of white matter microstructure. The combined use of these long diffusion times with short diffusion times (<10 ms) enabled by oscillating gradient spin echo (OGSE) waveforms can enable more sensitivity to changes of restrictive boundaries on the scale of white matter microstructure (e.g. membranes reflecting the axon diameters). Here, PGSE and OGSE images were acquired at 4.7 T from 20 healthy volunteers aged 20–73 years (10 males). Mean, radial, and axial diffusivity, as well as fractional anisotropy were calculated in the genu, body and splenium of the corpus callosum (CC). Monte Carlo simulations were also conducted to examine the relationship of intra- and extra-axonal radial diffusivity with diffusion time over a range of axon diameters and distributions. |
Year | DOI | Venue |
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2020 | 10.1016/j.neuroimage.2020.116533 | NeuroImage |
Keywords | Field | DocType |
DTI,Corpus callosum,OGSE,Aging,Sex,Monte Carlo simulation | Developmental psychology,Oscillation,Diffusion MRI,Diffusion imaging,Psychology,Axon,Radial diffusion,Spin echo,Corpus callosum,Nuclear magnetic resonance,Splenium | Journal |
Volume | ISSN | Citations |
210 | 1053-8119 | 0 |
PageRank | References | Authors |
0.34 | 0 | 6 |
Name | Order | Citations | PageRank |
---|---|---|---|
Pascal Tétreault | 1 | 0 | 0.34 |
Kevin D Harkins | 2 | 0 | 0.34 |
Corey A. Baron | 3 | 7 | 1.18 |
Rob Stobbe | 4 | 0 | 0.34 |
Mark D. Does | 5 | 98 | 6.30 |
Christian Beaulieu | 6 | 209 | 14.88 |