Name
Title | ||
|---|---|---|
Effect of blocking i<sub>kur</sub> on the genesis of action potential alternans in canine atrium |
Abstract | ||
|---|---|---|
The Kv1.5 channel-mediated, ultra-rapid delayed rectifier K
<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup>
current (I
<inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Kur</inf>
) is a promising target for anti-arrhythmic drugs due to its ‘atrial-selective’ property. However, it is unclear yet if blocking I
<inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Kur</inf>
can increase the alternans susceptibility in normal atria.This study aimed to investigate the effect of blocking I
<inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Kur</inf>
on the genesis of AP alternans associated with arrhythmogenesis. The updated canine atrial cell model developed by Ramirez et al. was used to implement the dynamic pacing protocol and the standard S1-S2 protocol to obtain rate dependent curves and restitution curves of AP duration (APD) and Ca
<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2+</sup>
transient which were further analyzed for the alternans susceptibility.Simulation results showed the prolonged AP and increased Ca
<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2+</sup>
transient (CaT) by blocking I
<inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Kur</inf>
. I
<inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Kur</inf>
block from 40% to 80% produced long-short-long-short APD and Ca
<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2+</sup>
transient alternans at pacing rate of ~ 2.3 Hz to 5 Hz. Further analysis showed that a possible mechanism for generating the observed alternans was due to the elevated plateau phase of AP by blocking I
<inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Kur</inf>
, which modulated APD and CaT via I
<inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CaL</inf>
. Our findings demonstrate that blocking I
<inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Kur</inf>
may promote the genesis of APD and CaT alternans, implying a latent pro-arrhythmic effect in normal atria. |
Year | DOI | Venue |
|---|---|---|
2019 | 10.23919/CinC49843.2019.9005821 | 2019 Computing in Cardiology (CinC) |
Keywords | DocType | ISSN |
observed alternans,CaT alternans,normal atria,action potential alternans,Kv1.5 channel-mediated,ultra-rapid delayed rectifier K,atrial-selective property,alternans susceptibility,AP alternans,updated canine atrial cell model,standard S1-S2 protocol,rate dependent curves,restitution curves,kur block,long-short-long-short APD,Ca2+ transient alternans,frequency 2.3 Hz to 5.0 Hz,Ca2+ | Conference | 2325-8861 |
ISBN | Citations | PageRank |
978-1-7281-5942-3 | 0 | 0.34 |
References | Authors | |
1 | 6 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Na Zhao | 1 | 37 | 16.03 |
| Qince Li | 2 | 7 | 9.91 |
| Kuanquan Wang | 3 | 1617 | 141.11 |
| Runnan He | 4 | 7 | 4.84 |
| Yongfeng Yuan | 5 | 11 | 7.40 |
| Henggui Zhang | 6 | 105 | 51.88 |