Paper Info
Title
Human adipose-derived mesenchymal stem cell-based medical microrobot system for knee cartilage regeneration in vivo.
Abstract
Targeted cell delivery by a magnetically actuated microrobot with a porous structure is a promising technique to enhance the low targeting efficiency of mesenchymal stem cell (MSC) in tissue regeneration. However, the relevant research performed to date is only in its proof-of-concept stage. To use the microrobot in a clinical stage, biocompatibility and biodegradation materials should be considered in the microrobot, and its efficacy needs to be verified using an in vivo model. In this study, we propose a human adipose-derived MSC-based medical microrobot system for knee cartilage regeneration and present an in vivo trial to verify the efficacy of the microrobot using the cartilage defect model. The microrobot system consists of a microrobot body capable of supporting MSCs, an electromagnetic actuation system for three-dimensional targeting of the microrobot, and a magnet for fixation of the microrobot to the damaged cartilage. Each component was designed and fabricated considering the accessibility of the patient and medical staff, as well as clinical safety. The efficacy of the microrobot system was then assessed in the cartilage defect model of rabbit knee with the aim to obtain clinical trial approval.
Year
DOI
Venue
2020
10.1126/scirobotics.aay6626
SCIENCE ROBOTICS
DocType
Volume
Issue
Journal
5
38
ISSN
Citations 
PageRank 
2470-9476
3
0.39
References 
Authors
0
17
Name
Order
Citations
PageRank
gwangjun go142.80
Sin-Gu Jeong230.39
Ami Yoo330.39
Jiwon Han430.39
Byungjeon Kang5104.84
Seokjae Kim630.39
Kim Tien Nguyen741.09
Zhen Jin830.39
Chang-Sei Kim9119.46
Yu Ri Seo1030.39
Ju Yeon Kang1130.39
Ju Yong Na1230.39
Eun Kyoo Song1330.39
Yongyeon Jeong1430.39
Jong Keun Seon1571.92
Jong-Oh Park1613338.86
Eunpyo Choi1776.77