Paper Info
Title
Sensing Performance Investigations on Two-Photon Fluorescent Probes for Detecting β -Amyloid in Alzheimer's Disease.
Abstract
Alzheimer's disease (AD) is one of the most common forms of senile disease. In recent years, the incidence of AD has been increasing significantly with the acceleration of the aging process of the global population. However, current clinical drugs can only alleviate the symptoms of AD patients without healing the disease fundamentally. Therefore, it is of great significance to develop an effective small molecule diagnostic reagent for the early diagnosis of AD. In this paper, we employ an integrated approach, including molecular docking simulation and quantum mechanics/molecular mechanics calculation, to investigate the sensing performance of a series of donor-acceptor structural probes for the marker protein of AD (beta-amyloid). Results show that the probes display evident fluorescence enhancement when bound to the beta-amyloid, suggesting the effect of the environment on the molecular properties. Especially, the two-photon absorption cross-section of the probes increase drastically in the beta-amyloid compared to that in vacuum, which results from the larger electron delocalization and dipole moment in the fibrillary-like environment. Thus, one can propose that the studied probes are capable of application in two-photon fluorescent imaging, particularly those containing naphthalene rings as the donor or with a longer spacer group. Our calculations elucidate the experimental measurements reasonably, and further establish possible structure-property relationships that can be used to design novel biocompatible two-photon fluorescent probes for the diagnosis of Alzheimer's.
Year
DOI
Venue
2020
10.3390/s20061760
SENSORS
Keywords
DocType
Volume
two-photon absorption,fluorescent probe,beta-amyloid detection,Alzheimer's disease
Journal
20
Issue
ISSN
Citations 
6.0
1424-8220
0
PageRank 
References 
Authors
0.34
0
5
Name
Order
Citations
PageRank
Yujin Zhang100.34
Ni Luan200.34
Kan Li35514.93
Jiancai Leng400.34
Yuzhong Qu572662.49