Paper Info
Title
Optical Coherence Tomography/Angiography-Guided Tumor Ablation With A Continuous-Wave Laser Diode
Abstract
Laser ablation can be an effective modality for treatment, but it is complicated to apply continuous-wave (CW) light sources for laser ablation because of the unpredictable photothermal damage. In this study, an integrated theranostic system combining a low-cost CW laser diode with optical coherence tomography (OCT)/angiography (OCTA) was utilized for the in vivo ablation of tumor tissues. To examine the effect of laser exposure on tissue scattering characteristics, the OCT backscattering intensities of non-ablated and ablated tissues were analyzed, and the effect on the skin microvasculature produced by laser ablation was quantitatively evaluated. Moreover, the integrated system and the proposed method were implemented for the treatment of skin tumor on the mouse model. The obtained results indicate that the developed laser ablation system can effectively remove tumor tissues with controllable photodamage under OCT/OCTA guidance and that the system cost may be significantly reduced by using the CW laser diode.
Year
DOI
Venue
2020
10.1109/ACCESS.2020.2976557
IEEE ACCESS
Keywords
DocType
Volume
Laser ablation, Semiconductor lasers, Laser beams, Tumors, Fiber lasers, Diode lasers, Skin, Laser diode, laser ablation, biomedical optical imaging, angiography, medical diagnostic imaging, biophotonics
Journal
8
ISSN
Citations 
PageRank 
2169-3536
0
0.34
References 
Authors
0
6
Name
Order
Citations
PageRank
Meng-Tsan Tsai101.69
Wen-Ju Chen200.34
Ting-Yen Tsai300.34
Hsiang-Chieh Lee471.48
Chun-Chieh Wang500.34
Ya-Ju Lee600.68