Abstract | ||
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Molecular imaging is becoming essential for precision targeted radiation therapy, yet progress is hindered from a lack of integrated imaging and treatment systems. We report the development of a prototype positron emission tomography (PET) scanner integrated into a commercial cone beam computed tomography (CBCT) based small animal irradiation system for molecular-image-guided, targeted external beam radiation therapy. The PET component consists of two rotating Hamamatsu time-of-flight PET modules positioned with a bore diameter of 101.6 mm and a radial field-of-view of 53.1 mm. The measured energy resolution after linearity correction at 511 KeV was 12.9% and the timing resolution was 283.6 ps. The measured spatial resolutions at the field-of-view center and 5 mm off the radial center were 2.6 mm x 2.6 mm x 1.6 mm and 2.6 mm x 2.6 mm x 2.7 mm respectively. F-18-Fluorodeoxyglucose-based PET imaging of a NEMA NU 4-2008 phantom resolved cylindrical volumes with diameters as small as 3 mm. To validate the system in-vivo, we performed Cu-64-DOTA-M5A PET and computed tomography (CT) imaging of carcinoembryonic antigen (CEA)-positive colorectal cancer in athymic nude mice and compared the results with a commercially available Siemens Inveon PET/CT system. The prototype PET system performed comparably to the Siemens system for identifying the location, size, and shape of tumors. Regions of heterogeneous Cu-64-DOTA-M5A uptake were observed. Using Cu-64-DOTA-M5A PET and CT images, a Monte Carlo-based radiation treatment plan was created to escalate the dose to the Cu-64-DOTA-M5A-based, highly active, biological target volume while largely sparing the normal tissue. Results demonstrate the feasibility of molecular-image-guided treatment plans using the prototype theranostic system. |
Year | DOI | Venue |
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2019 | 10.1109/ACCESS.2019.2944683 | IEEE ACCESS |
Keywords | DocType | Volume |
Molecular imaging, multimodal imaging, targeted radiation, theranostic | Journal | 7 |
ISSN | Citations | PageRank |
2169-3536 | 0 | 0.34 |
References | Authors | |
0 | 17 |
Name | Order | Citations | PageRank |
---|---|---|---|
Ekaterina Mikhaylova | 1 | 0 | 0.34 |
Jamison Brooks | 2 | 0 | 0.34 |
Darren M. Zuro | 3 | 0 | 0.34 |
Farouk Nouizi | 4 | 0 | 0.34 |
Maciej Kujawski | 5 | 0 | 0.34 |
Srideshikan Sargur Madabushi | 6 | 0 | 0.34 |
Jinyi Qi | 7 | 284 | 35.82 |
Mengxi Zhang | 8 | 0 | 0.34 |
Junie Chea | 9 | 0 | 0.34 |
Erasmus K. Poku | 10 | 0 | 0.34 |
Nicole Bowles | 11 | 0 | 0.34 |
Jeffrey Y. C. Wong | 12 | 0 | 0.34 |
John E. Shively | 13 | 0 | 0.34 |
Paul J. Yazaki | 14 | 0 | 0.34 |
Gultekin Gulsen | 15 | 0 | 1.35 |
Simon R. Cherry | 16 | 6 | 3.17 |
Hui Susanta K | 17 | 0 | 0.68 |