Paper Info
Title
Development of Artificial Skin Using Keratin Film for Evaluation of Puncture Performance of Microneedle.
Abstract
Humans do not feel pain when bitten by mosquitos; therefore, we have attempted to develop a microneedle that mimics the puncturing mechanism of mosquitos. We have quantitatively evaluated the puncturing performance of the developed microneedle by puncturing an artificial skin made from polydimethylsiloxane (PDMS), a kind of silicon rubber. Unlike the mono-layered PDMS, however, animal skin including human skin is structured to have a hard stratum corneum, epidermis and dermis over soft subcutaneous tissue. In this paper, we propose an artificial skin having a two-layered hard/soft structure, constructed from PDMS with a human-hair-derived keratin film adhered onto the top surface. We evaluated the hardness of the keratin film (Young's modulus) and found that it could qualitatively simulate the hard layers of the skin including the stratum corneum. The artificial skin we developed reproduced the following phenomena: the decrease in resistance force of animal skin at the point when the needle penetrates the surface followed by variation in resistance due to the stick-slip phenomenon as the needle penetrates more deeply.
Year
DOI
Venue
2020
10.20965/jrm.2020.p0351
JOURNAL OF ROBOTICS AND MECHATRONICS
Keywords
DocType
Volume
microneedle,mosquito,skin,stratum corneum,keratin
Journal
32
Issue
ISSN
Citations 
SP2
0915-3942
0
PageRank 
References 
Authors
0.34
0
11
Name
Order
Citations
PageRank
Ryo Nishino100.34
Seiji Aoyagi22514.63
Masato Suzuki327.57
Atsushi Ueda400.34
Yuki Okumura500.34
Tomokazu Takahashi6322100.16
Ryota Hosomi700.68
Kenji Fukunaga800.68
Daisuke Uta900.68
Tomonori Takazawa1000.34
Toshihiro Fujii1100.34