Paper Info
Title
Effect of Inner Diameter and Anticoagulation Coating in a Microneedle on its Blood Suction Performance.
Abstract
As a part of the development of a minimally invasive hollow microneedle designed to mimic a mosquito proboscis, we evaluated the relationship between the needle inner diameter (ID) and blood sucking performance. If the ID is thinned to reduce pain upon piercing skin, blood could clog the tube owing to coagulation, and a sufficient volume of blood might not be obtained. In this study, laser stereo-lithography is used to easily fabricate microtubes of several sizes, at 20-50 mu m ID and a fixed length of 500 mu m, through which human whole blood is sucked by a vacuum pump. The results indicate that the ID of the tube must be at least 20 mu m to prevent hemolysis and at least 50 mu m to enable extraction of 200 mu L of blood, which is necessary for general blood tests. Moreover, anticoagulant coating applied on the inner wall prevents the clogging of blood and increases the volume of extracted blood.
Year
DOI
Venue
2020
10.20965/jrm.2020.p0362
JOURNAL OF ROBOTICS AND MECHATRONICS
Keywords
DocType
Volume
microneedle,hemolysis,coagulation,mosquito,stereo-lithographic tube
Journal
32
Issue
ISSN
Citations 
SP2
0915-3942
0
PageRank 
References 
Authors
0.34
0
4
Name
Order
Citations
PageRank
Seiji Aoyagi12514.63
Ryosuke Nomura200.34
Tomokazu Takahashi3322100.16
Masato Suzuki427.57