Paper Info
Title
IRIS3: integrated cell-type-specific regulon inference server from single-cell RNA-Seq.
Abstract
A group of genes controlled as a unit, usually by the same repressor or activator gene, is known as a regulon. The ability to identify active regulons within a specific cell type, i.e., cell-type-specific regulons (CTSR), provides an extraordinary opportunity to pinpoint crucial regulators and target genes responsible for complex diseases. However, the identification of CTSRs from single-cell RNA-Seq (scRNA-Seq) data is computationally challenging. We introduce IRIS3, the first-of-its-kind web server for CTSR inference from scRNA-Seq data for human and mouse. IRIS3 is an easy-to-use server empowered by over 20 functionalities to support comprehensive interpretations and graphical visualizations of identified CTSRs. CTSR data can be used to reliably characterize and distinguish the corresponding cell type from others and can be combined with other computational or experimental analyses for biomedical studies. CTSRs can, therefore, aid in the discovery of major regulatory mechanisms and allow reliable constructions of global transcriptional regulation networks encoded in a specific cell type. The broader impact of IRIS3 includes, but is not limited to, investigation of complex diseases hierarchies and heterogeneity, causal gene regulatory network construction, and drug development. IRIS3 is freely accessible from https://bmbl.bmi.osumc.edu/iris3/ with no login requirement.
Year
DOI
Venue
2020
10.1093/nar/gkaa394
NUCLEIC ACIDS RESEARCH
DocType
Volume
Issue
Journal
48
W1
ISSN
Citations 
PageRank 
0305-1048
0
0.34
References 
Authors
0
9
Name
Order
Citations
PageRank
Anjun Ma1143.73
Cankun Wang221.38
Yuzhou Chang300.68
Faith H Brennan400.34
Adam McDermaid582.58
Bingqiang Liu6434.88
Zhang Chi7107.64
Phillip G Popovich800.34
Qin Ma95714.76