Paper Info
Title
Towards Clinical Translation of LED-Based Photoacoustic Imaging: A Review.
Abstract
Photoacoustic imaging, with the capability to provide simultaneous structural, functional, and molecular information, is one of the fastest growing biomedical imaging modalities of recent times. As a hybrid modality, it not only provides greater penetration depth than the purely optical imaging techniques, but also provides optical contrast of molecular components in the living tissue. Conventionally, photoacoustic imaging systems utilize bulky and expensive class IV lasers, which is one of the key factors hindering the clinical translation of this promising modality. Use of LEDs which are portable and affordable offers a unique opportunity to accelerate the clinical translation of photoacoustics. In this paper, we first review the development history of LED as an illumination source in biomedical photoacoustic imaging. Key developments in this area, from point-source measurements to development of high-power LED arrays, are briefly discussed. Finally, we thoroughly review multiple phantom, ex-vivo, animal in-vivo, human in-vivo, and clinical pilot studies and demonstrate the unprecedented preclinical and clinical potential of LED-based photoacoustic imaging.
Year
DOI
Venue
2020
10.3390/s20092484
SENSORS
Keywords
DocType
Volume
photoacoustic,LED,clinic,optical imaging
Journal
20
Issue
ISSN
Citations 
9
1424-8220
0
PageRank 
References 
Authors
0.34
0
8
Name
Order
Citations
PageRank
Yunhao Zhu100.34
Ting Feng200.68
Qian Cheng321.09
Xueding Wang443.19
Sidan Du531431.20
Naoto Sato600.34
Jie Yuan7226.04
Mithun Kuniyil Ajith Singh832.24