Name
Title | ||
|---|---|---|
SPR Biosensor Based on Polymer Multi-Mode Optical Waveguide and Nanoparticle Signal Enhancement. |
Abstract | ||
|---|---|---|
We present a surface plasmon resonance (SPR) biosensor that is based on a planar-optical multi-mode (MM) polymer waveguide structure applied for the detection of biomolecules in the lower nano-molar (nM) range. The basic sensor shows a sensitivity of 608.6 nm/RIU when exposed to refractive index changes with a measurement resolution of 4.3 x 10(-3) RIU. By combining the SPR sensor with an aptamer-functionalized, gold-nanoparticle (AuNP)-enhanced sandwich assay, the detection of C-reactive protein (CRP) in a buffer solution was achieved with a response of 0.118 nm/nM. Due to the multi-mode polymer waveguide structure and the simple concept, the reported biosensor is well suited for low-cost disposable lab-on-a-chip applications and can be used with rather simple and economic devices. In particular, the sensor offers the potential for fast and multiplexed detection of several biomarkers on a single integrated platform. |
Year | DOI | Venue |
|---|---|---|
2020 | 10.3390/s20102889 | SENSORS |
Keywords | DocType | Volume |
surface plasmon resonance (SPR),sensor,planar-optical,multi-mode,waveguide,biosensor,aptamer,gold-nanoparticle,lab-on-a-chip | Journal | 20 |
Issue | ISSN | Citations |
10 | 1424-8220 | 1 |
PageRank | References | Authors |
0.39 | 0 | 5 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Johanna-Gabriela Walter | 1 | 1 | 1.06 |
| Alina Eilers | 2 | 1 | 0.39 |
| Lourdes Shanika Alwis | 3 | 7 | 1.99 |
| bernhard roth | 4 | 9 | 5.27 |
| kort bremer | 5 | 8 | 3.44 |