Title
Separation of Metabolite and Macromolecule Signals for 1 H-Mrsi Using Learned Nonlinear Models.
Abstract
This paper presents a novel method to reconstruct and separate metabolite and macromolecule (MM) signals in 1 H magnetic resonance spectroscopic imaging (MRS I) data using learned nonlinear models. Specifically, deep autoencoder (DAE) networks were constructed and trained to learn the nonlinear low-dimensional manifolds, where the metabolite and MM signals reside individually. A regularized reconstruction formulation is proposed to integrate the learned models with signal encoding model to reconstruct and separate the metabolite and MM components. An efficient algorithm was developed to solve the associated optimization problem. The performance of the proposed method has been evaluated using simulation and experimental 1 H-MRSI data. Efficient low-dimensional signal representation of the learned models and improved metabolite/MM separation over the standard parametric fitting based approach have been demonstrated.
Year
DOI
Venue
2020
10.1109/ISBI45749.2020.9098365
ISBI
DocType
Citations 
PageRank 
Conference
0
0.34
References 
Authors
0
3
Name
Order
Citations
PageRank
Yahang Li100.34
Zepeng Wang200.34
Fan Lam3509.14