Name
Title | ||
|---|---|---|
Circuits with broken fibration symmetries perform core logic computations in biological networks. |
Abstract | ||
|---|---|---|
We show that logic computational circuits in gene regulatory networks arise from a fibration symmetry breaking in the network structure. From this idea we implement a constructive procedure that reveals a hierarchy of genetic circuits, ubiquitous across species, that are surprising analogues to the emblematic circuits of solid-state electronics: starting from the transistor and progressing to ring oscillators, current-mirror circuits to toggle switches and flip-flops. These canonical variants serve fundamental operations of synchronization and clocks (in their symmetric states) and memory storage (in their broken symmetry states). These conclusions introduce a theoretically principled strategy to search for computational building blocks in biological networks, and present a systematic route to design synthetic biological circuits. |
Year | DOI | Venue |
|---|---|---|
2020 | 10.1371/journal.pcbi.1007776 | PLOS COMPUTATIONAL BIOLOGY |
DocType | Volume | Issue |
Journal | 16 | 6 |
ISSN | Citations | PageRank |
1553-734X | 0 | 0.34 |
References | Authors | |
0 | 6 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Ian Leifer | 1 | 0 | 0.68 |
| Flaviano Morone | 2 | 139 | 6.72 |
| Saulo D. S. Reis | 3 | 41 | 2.77 |
| Jose S. Andrade, Jr. | 4 | 4 | 1.81 |
| Mariano Sigman | 5 | 79 | 13.24 |
| Hernán A Makse | 6 | 0 | 1.01 |