Title | ||
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fMRI detects bilateral brain network activation following unilateral chemogenetic activation of direct striatal projection neurons. |
Abstract | ||
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Abnormal structural and functional connectivity in the striatum during neurological disorders has been reported using functional magnetic resonance imaging (fMRI), although the effects of cell-type specific neuronal stimulation on fMRI and related behavioral alterations are not well understood. In this study, we combined DREADD technology with fMRI (“chemo-fMRI”) to investigate alterations of spontaneous neuronal activity. These were induced by the unilateral activation of dopamine D1 receptor-expressing neurons (D1-neurons) in the mouse dorsal striatum (DS). After clozapine (CLZ) stimulation of the excitatory DREADD expressed in D1-neurons, the fractional amplitude of low frequency fluctuations (fALFF) increased bilaterally in the medial thalamus, nucleus accumbens and cortex. In addition, we found that the gamma-band of local field potentials was increased in the stimulated DS and cortex bilaterally. These results provide insights for better interpretation of cell type-specific activity changes in fMRI. |
Year | DOI | Venue |
---|---|---|
2020 | 10.1016/j.neuroimage.2020.117079 | NeuroImage |
Keywords | DocType | Volume |
Designer receptors exclusively activated by designer drugs,Magnetic resonance imaging,Clozapine,Clozapine-N-Oxide,Striatum,Drd1-receptor-expressing striatal projection neurons | Journal | 220 |
ISSN | Citations | PageRank |
1053-8119 | 1 | 0.36 |
References | Authors | |
0 | 8 |
Name | Order | Citations | PageRank |
---|---|---|---|
Yuki Nakamura | 1 | 1 | 0.36 |
Yukari Nakamura | 2 | 1 | 0.36 |
Assunta Pelosi | 3 | 1 | 0.36 |
Boucif Djemai | 4 | 1 | 0.36 |
Clément Debacker | 5 | 1 | 0.36 |
Denis Hervé | 6 | 1 | 0.36 |
Jean-Antoine Girault | 7 | 2 | 0.85 |
Tomokazu Tsurugizawa | 8 | 1 | 0.36 |