Paper Info
Title
Metabolic networks of the Nicotiana genus in the spotlight: content, progress and outlook
Abstract
Manually curated metabolic databases residing at the Sol Genomics Network comprise two taxon-specific databases for the Solanaceae family, i.e. SolanaCyc and the genus Nicotiana, i.e. NicotianaCyc as well as six species-specific databases for Nicotiana tabacum TN90, N. tabacum K326, Nicotiana benthamiana, N. sylvestris, N. tomentosiformis and N. attenuata. New pathways were created through the extraction, examination and verification of related data from the literature and the aid of external database guided by an expert-led curation process. Here we describe the curation progress that has been achieved in these databases since the first release version 1.0 in 2016, the curation flow and the curation process using the example metabolic pathway for cholesterol in plants. The current content of our databases comprises 266 pathways and 36 superpathways in SolanaCyc and 143 pathways plus 21 superpathways in NicotianaCyc, manually curated and validated specifically for the Solanaceae family and Nicotiana genus, respectively. The curated data have been propagated to the respective Nicotiana-specific databases, which resulted in the enrichment and more accurate presentation of their metabolic networks. The quality and coverage in those databases have been compared with related external databases and discussed in terms of literature support and metabolic content.
Year
DOI
Venue
2021
10.1093/bib/bbaa136
BRIEFINGS IN BIOINFORMATICS
Keywords
DocType
Volume
taxon-specific databases, manual curation, data quality, literature coverage, database development
Journal
22
Issue
ISSN
Citations 
3
1467-5463
0
PageRank 
References 
Authors
0.34
0
5
Name
Order
Citations
PageRank
Hartmut Foerster121329.50
James N. D. Battey200.68
Nicolas Sierro300.34
Nikolai V. Ivanov482.75
Lukas A. Mueller575990.87