Title
COVID-19 therapy target discovery with context-aware literature mining
Abstract
The abundance of literature related to the widespread COVID-19 pandemic is beyond manual inspection of a single expert. Development of systems, capable of automatically processing tens of thousands of scientific publications with the aim to enrich existing empirical evidence with literature-based associations is challenging and relevant. We propose a system for contextualization of empirical expression data by approximating relations between entities, for which representations were learned from one of the largest COVID-19-related literature corpora. In order to exploit a larger scientific context by transfer learning, we propose a novel embedding generation technique that leverages SciBERT language model pretrained on a large multi-domain corpus of scientific publications and fine-tuned for domain adaptation on the CORD-19 dataset. The conducted manual evaluation by the medical expert and the quantitative evaluation based on therapy targets identified in the related work suggest that the proposed method can be successfully employed for COVID-19 therapy target discovery and that it outperforms the baseline FastText method by a large margin.
Year
DOI
Venue
2020
10.1007/978-3-030-61527-7_8
DS
DocType
Citations 
PageRank 
Conference
0
0.34
References 
Authors
0
7
Name
Order
Citations
PageRank
Matej Martinc122.08
Blaž Škrlj201.35
Sergej Pirkmajer300.34
Nada Lavrac42004635.45
Bojan Cestnik5716262.57
Martin Marzidovšek600.34
Senja Pollak72016.92