Name
Title | ||
|---|---|---|
An Electrochemical Biochip for Measuring Low Concentrations of Analytes With Adjustable Temporal Resolutions |
Abstract | ||
|---|---|---|
Electrochemical micro-sensors made of nanographitic (NG) carbon materials could offer high sensitivity and support voltammetry measurements at vastly different temporal resolutions. Here, we implement a configurable CMOS biochip for measuring low concentrations of bio-analytes by leveraging these advantageous features of NG micro-sensors. In particular, the core of the biochip is a discrete-time ΔΣ modulator, which can be configured for optimal power consumption according to the temporal resolution requirements of the sensing experiments while providing a required precision of ≈13 effective number of bits. We achieve this new functionality by developing a design methodology using the physical models of transistors, which allows the operating region of the modulator to be switched on-demand between weak and strong inversion. We show the application of this configurable biochip through in-vitro measurements of dopamine with concentrations as low as 50 nM and 200 nM at temporal resolutions of 100 ms and 10 s, respectively. |
Year | DOI | Venue |
|---|---|---|
2020 | 10.1109/TBCAS.2020.3009303 | IEEE Transactions on Biomedical Circuits and Systems |
Keywords | DocType | Volume |
Dopamine,Electrochemical Techniques,Equipment Design,Graphite,Lab-On-A-Chip Devices,Nanostructures,Semiconductors | Journal | 14 |
Issue | ISSN | Citations |
4 | 1932-4545 | 0 |
PageRank | References | Authors |
0.34 | 0 | 7 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Kae-Dyi You | 1 | 6 | 2.50 |
| Edoardo Cuniberto | 2 | 0 | 0.34 |
| Shao-Cheng Hsu | 3 | 0 | 0.34 |
| Bohan Wu | 4 | 0 | 1.01 |
| Zhujun Huang | 5 | 0 | 0.34 |
| Xiaochang Pei | 6 | 0 | 0.34 |
| Davood Shahrjerdi | 7 | 12 | 4.40 |