Paper Info
Title
SurvivalMeth: a web server to investigate the effect of DNA methylation-related functional elements on prognosis
Abstract
Aberrant DNA methylation is a fundamental characterization of epigenetics for carcinogenesis. Abnormality of DNA methylation-related functional elements (DMFEs) may lead to dysfunction of regulatory genes in the progression of cancers, contributing to prognosis of many cancers. There is an urgent need to construct a tool to comprehensively assess the impact of DMFEs on prognosis. Therefore, we developed SurvivalMeth (http://bio-bigdatathrbmu.edu.cn/surviyalmeth) to explore the prognosis-related DMFEs, which documented many kinds of DMFEs, including 309,465 CpG island-related elements, 104,748 transcript-related elements, 77,634 repeat elements, as well as cell-type specific 1,689,653 super enhancers (SE) and 1,304,902 CTCF binding regions for analysis. SurvivalMeth is a convenient tool which collected DNA methylation profiles of 36 cancers and allowed users to query their genes of interest in different datasets for prognosis. Furthermore, SurvivalMeth not only integrated different combinations, including single DMFE, multiple DMFEs, SEs and clinical data, to perform survival analysis on preupload data but also allowed for uploading customized DNA methylation profile of DMFEs from various diseases to analyze. SurvivalMeth provided a comprehensive resource and automated analysis for prognostic DMFEs, including DMFE methylation level, correlation analysis, clinical analysis, differential analysis, DMFE annotation, survival-related detailed result and visualization of survival analysis. In summary, we believe that SurvivalMeth will facilitate prognostic research of DMFEs in diverse cancers.
Year
DOI
Venue
2021
10.1093/bib/bbaa162
BRIEFINGS IN BIOINFORMATICS
Keywords
DocType
Volume
DNA methylation, functional element, survival analysis, cancer, SurvivalMeth, web server
Journal
22
Issue
ISSN
Citations 
3
1467-5463
0
PageRank 
References 
Authors
0.34
0
10
Name
Order
Citations
PageRank
Chunlong Zhang152.48
Ning Zhao200.34
Xue Zhang301.35
Jun Xiao400.34
Junyi Li501.01
Dezhong Lv600.68
Weiwei Zhou701.01
Yongsheng Li812.71
Juan Xu923.07
Xia Li1058873.46