Paper Info
Title
The Influence Of Macro-Textural Designs Over Implant Surface On Bone On-Growth: A Computational Mechanobiology Based Study
Abstract
The longerterm secondary stability of an uncemented implant depends primarily on the quality and extent of bone in-growth or on-growth at the bone-implant interface. Investigations are warranted to predict the influences of implant macro-textures on bone on-growth pattern. Mechanoregulatory tissue differentiation algorithms can predict such patterns effectively. There is, however, a dearth of volumetric in silico study to assess the influence of macro-textures on bone growth. The present study investigated the influence of macro-textural grooves/ribs on changes in tissue formation at the bone-implant interface by carrying out a 3D finite element (FE) analysis. Three distinct macro-textures, loosely based on commercially viable hip stem models, were comparatively assessed for varying levels of interfacial micromotion. The study predicted elevated fibrogenesis and chondrogenesis, fol-lowed by a suppressed osteogenesis for higher levels of micromotion (60 mu m and 100 mu m), resulting in weak bone-implant interface strength. However, small judicious modifications in implant surface texture may enhance bone growth to a considerable extent. The numerical scheme can further be used as a template for more rigorous parametric and multi-scale studies.
Year
DOI
Venue
2020
10.1016/j.compbiomed.2020.103937
COMPUTERS IN BIOLOGY AND MEDICINE
Keywords
DocType
Volume
Uncemented implant, Bone on-growth, Macro-texture, Mechanoregulation, Micromotion, Finite element analysis
Journal
124
ISSN
Citations 
PageRank 
0010-4825
0
0.34
References 
Authors
0
3
Name
Order
Citations
PageRank
Rajdeep Ghosh100.34
Souptick Chanda200.34
Debabrata Chakraborty3273.55