Paper Info
Title
Infusion Mechanisms in Brain White Matter and Their Dependence on Microstructure: An Experimental Study of Hydraulic Permeability
Abstract
<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> Hydraulic permeability is a topic of deep interest in biological materials because of its important role in a range of drug delivery-based therapies. The strong dependence of permeability on the geometry and topology of pore structure and the lack of detailed knowledge of these parameters in the case of brain tissue makes the study more challenging. Although theoretical models have been developed for hydraulic permeability, there is limited consensus on the validity of existing experimental evidence to complement these models. In the present study, we measure the permeability of white matter (WM) of fresh ovine brain tissue considering the localised heterogeneities in the medium using an infusion-based experimental set up, <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">iPerfusion</i> . We measure the flow across different parts of the WM in response to applied pressures for a sample of specific dimensions and calculate the permeability from directly measured parameters. Furthermore, we directly probe the effect of anisotropy of the tissue on permeability by considering the directionality of tissue on the obtained values. Additionally, we investigate whether WM hydraulic permeability changes with post-mortem time. To our knowledge, this is the first report of experimental measurements of the localised WM permeability, also demonstrating the effect of axon directionality on permeability. This work provides a significant contribution to the successful development of intra-tumoural infusion-based technologies, such as convection-enhanced delivery (CED), which are based on the delivery of drugs directly by injection under positive pressure into the brain.
Year
DOI
Venue
2021
10.1109/TBME.2020.3024117
IEEE Transactions on Biomedical Engineering
Keywords
DocType
Volume
Animals,Anisotropy,Brain,Drug Delivery Systems,Permeability,Sheep,White Matter
Journal
68
Issue
ISSN
Citations 
4
0018-9294
0
PageRank 
References 
Authors
0.34
0
10
Name
Order
Citations
PageRank
Asad Jamal100.34
Maria Teresa Mongelli200.34
Marco Vidotto300.34
Michael Madekurozwa400.34
Andrea Bernardini500.34
Darryl R. Overby600.68
Elena De Momi724252.77
Ferdinando Rodriguez y Baena816226.06
Joseph M Sherwood900.34
Daniele Dini1043.25